ABSTRACT
Our previous experimental work with tissue plasminogen activator (TPA) suggested the possibility of the clearance of vitreous hemorrhage by repetitive injections of low-dose TPA. We therefore investigated in rabbits the effect of both repeated injections of TPA and the change of the integrity of the vitreous body on the clearance of vitreous hemorrhage. Vitreous hemorrhage was produced by intravitreal injection of 0.05 ml of autologous whole blood in the pigmented rabbit eyes with intact vitreous or gas-compressed vitreous. Three intravitreal injections of 3-g TPA (total dose of 9 microgram), separated by 7-day intervals, were performed. The endpoint for vitreous hemorrhage clearance was defined as clear visualization of the posterior central retina of the rabbits. Regardless of whether gas compression vitrectomy was performed, repeated injections of low-dose TPA resulted in rapid clearance of fresh vitreous hemorrhage in approximately two to three weeks after the last TPA injection. No evidence of retinal toxicity was seen in all experimental groups. Repetitive injections of low-dose TPA may be effective in the treatment of fresh vitreous hemorrhage.
Subject(s)
Animals , Rabbits , Disease Models, Animal , Injections , Tissue Plasminogen Activator/administration & dosage , Vitreous Body/drug effects , Vitreous Hemorrhage/drug therapyABSTRACT
We performed the radioimmunoassay to detect the hepatitis B surface antigen(HBsAg) in the tear. Among 70 patients who have positive reactions for HBsAg in blood, 53 patients(75.71%) were positive for HBsAg in tear. Among the various groups of hepatitis, the most positive reaction for HBsAg in tear was higher in serum HBeAg positive group(92.68%) than in serum HBeAg negative group(51.72%). So we emphasize the possibility of transmission of hepatitis B virus infection via tear.
Subject(s)
Humans , Hepatitis B e Antigens , Hepatitis B Surface Antigens , Hepatitis B virus , Hepatitis B , Hepatitis , Radioimmunoassay , TearsABSTRACT
We performed the radioimmunoassay to detect the hepatitis B surface antigen (HBsAg) in the tear. Among 70 patients who have positive reactions for HBsAg in blood, 53 patients (75.71 %) were positive for HBsAg in tear. Among the various groups of hepatitis, the most positive reaction for HBsAg in tear was higher in serum HBeAg positive group (92.68%) than in serum HBeAg negative group (51.72%). So we emphasize the possibility of transmission of hepatitis B virus infection via tear.